Structures

Guanine riboswitch

Chem. Biol. 2004

Adenine riboswitch

Chem. Biol. 2004

Diels-Alder ribozyme

Nat. Struct. Mol. Biol. 2005

  • 1YKQ – Free
  • 1YKV – Bound to reaction product
  • 1YLS – Bound to reaction product, Se derivative

Thiamine pyrophosphate riboswitch

Nature 2006

Lysine riboswitch

Nature 2008

  • 3DIS – Free form
  • 3DIL – Bound to lysine
  • 3DIO – Iridium hexammine soak
  • 3DIM – Cs+ soak
  • 3DIY – Mn2+ soak
  • 3DJ2 – Tl+ soak
  • 3DIX – K+ anomalous signal
  • 3DIZ – Without Mg2+
  • 3DIG – Bound to S-(2-aminoethyl)-L-cysteine
  • 3DIQ – Bound to homoarginine
  • 3DIR – Bound to N6-1-iminoethyl-L-Lysine
  • 3DJ0 – Bound to L-4-oxalysine

Flavin mononucleotide riboswitch

Nature 2009

  • 3F2Q – Bound to FMN
  • 3F2T – Iridium hexammine soak
  • 3F2W – Ba2+ soak
  • 3F2X – Cs2+ soak
  • 3F2Y – Mn2+ soak
  • 3F30 – Cobalt hexammine soak
  • 3F4E – Split RNA
  • 3F4G – Bound to riboflavin
  • 3F4H – Bound to roseoflavin

Glycine ribposwitch

Mol. Cell 2010

  • 3OWI – Bound to glycine
  • 3OWW – Bound to glycine
  • 3OWZ – Iridium hexammine soak
  • 3OXE – Mn2+ soak
  • 3OXJ – Ba2+ soak
  • 3OXM – Tl+ soak
  • 3OX0 – Free
  • 3OXB – Single mutant
  • 3OXD – Double mutant

2′-deoxyguanosine riboswitch

Nat. Chem. Biol. 2011

  • 3SKI – Bound to 2′-deoxuguanosine
  • 3SKL – Iridium hexammine soak
  • 3SKR – Cobalt hexammine soak
  • 3SKT – Mn2+ soak
  • 3SKW – Cs2+ soak
  • 3SKZ – Bound to guanosine
  • 3SLM – Bound to 2′-deoxyguanosine-5′-monophosphate
  • 3SLQ – Bound to guanosine-5′-monophosphate

Tetrahydrofolate riboswitch

Proc. Natl. Acad. Sci. USA 2011

  • 3SUH – Bound to 5-formyl-THF
  • 3SUX – Bound to THF
  • 3SUY – Free

Vitamin B12 riboswitch

Nat. Struct. Mol. Biol. 2012

c-di-AMP riboswitch

Nat. Chem. Biol. 2014

  • 4QK8Thermoanaerobacter pseudethanolicus riboswitch
  • 4QK9Thermovirga lienii riboswitch
  • 4QKAThermoanaerobacter pseudethanolicus riboswitch, iridium hexammine soak

RppH bound to RNA and in free state

J Biol. Chem. 2015

  • 4S2V – Free RppH, KI soak
  • 4S2W – Free RppH, sulfate bound
  • 4S2X – RppH-RNA with two Mg2+ cations
  • 4S2Y – RppH-RNA with three Mg2+ cations

Complex between human FMRP RGG motif and G-quadruplex RNA

Proc. Natl. Acad. Sci. U.S.A. 2015