We are a biochemical and structural biology laboratory focused on fundamental cellular activities involving RNA molecules
We are located in the Department of Biochemistry and Molecular Pharmacology in the New York University School of Medicine at NYU Langone Medical Center.
RNA plays a multifaceted role in all living organisms. In addition to conveying genetic instructions for protein synthesis, RNA participates in other important biological processes as a component of cellular machineries and a modulator of gene expression. The major impact of RNA molecules on the control of gene expression has been highlighted by recent discoveries of small regulatory RNAs, long non-coding RNAs, and regulatory RNA elements in the non-coding regions of mRNAs. Despite their simple composition, RNA molecules can fold into intricate three-dimensional structures that expand the utility of RNA beyond that of the information carrier. Both RNA sequences and spatial structures are key for interactions with partners and assembly of functional complexes controlling gene expression.
We use a combination of biophysical methods, biochemical techniques, and structural approaches, including X-ray crystallography and cryo-electron microscopy, to elucidate molecular mechanisms of fundamental cellular processes associated with biosynthesis of mRNA, metabolism of RNA, and RNA-mediated gene expression control.
Happy Holidays! No party this year…
Our News & Views on a new fluorescent tag coined Squash has been published in Nature Chemical Biology. Congratulations to the Jaffrey and Ferré-D’Amaré laboratories on their excellent work on making and studying “Squash”!
Our collaborative study on H2S inhibitors with the Nudler lab has been published in Science! Ashok is the first coauthor!
Congratulations to Jake with the Ph.D. defense!