Structures

PRPP riboswitch

Nat. Chem. Biol. 2018

6DLT – Native
6DLR – Iridium hexammine soak
6DLQ – Mn²⁺ soak
6DLS – Tl⁺ soak
6DNR – apo structure

ppGpp riboswitch

Nat. Chem. Biol. 2018

6DMC – Native
6DMD – Mn²⁺ soak
6DME – Tl⁺ soak

Crystal structure of RppH-DapF complex

Nucleic Acids Research 2018

• 6D13  – Crystal structure of RppH-DapF complex
• 6D1Q – Crystal structure of RppH-DapF complex, monomer
• 6D1V – Crystal structure of RppH-DapF complex, monomer bound to RNA

S15-rRNA complex

Nature Struct. Biol. 2000

• 1DK1

Guanine riboswitch

Chem. Biol. 2004

• 1Y27

Adenine riboswitch

Chem. Biol. 2004

• 1Y26

Diels-Alder ribozyme

Nat. Struct. Mol. Biol. 2005

• 1YKQ – Free
• 1YKV – Bound to reaction product
• 1YLS – Bound to reaction product, Se derivative

Thiamine pyrophosphate riboswitch

Nature 2006

• 2GDI

Lysine riboswitch

Nature 2008

• 3DIS – Free form
• 3DIL – Bound to lysine
• 3DIO – Iridium hexammine soak
• 3DIM – Cs⁺ soak
• 3DIY – Mn²⁺ soak
• 3DJ2 – Tl⁺ soak
• 3DIX – K⁺ anomalous signal
• 3DIZ – Without Mg²⁺
• 3DIG – Bound to S-(2-aminoethyl)-L-cysteine
• 3DIQ – Bound to homoarginine
• 3DIR – Bound to N6-1-iminoethyl-L-Lysine
• 3DJ0 – Bound to L-4-oxalysine

Flavin mononucleotide riboswitch

Nature 2009

• 3F2Q – Bound to FMN
• 3F2T – Iridium hexammine soak
• 3F2W – Ba²⁺ soak
• 3F2X – Cs²⁺ soak
• 3F2Y – Mn²⁺ soak
• 3F30 – Cobalt hexammine soak
• 3F4E – Split RNA
• 3F4G – Bound to riboflavin
• 3F4H – Bound to roseoflavin

Glycine ribposwitch

Mol. Cell 2010

• 3OWI – Bound to glycine
• 3OWW – Bound to glycine
• 3OWZ – Iridium hexammine soak
• 3OXE – Mn²⁺ soak
• 3OXJ – Ba²⁺ soak
• 3OXM – Tl⁺ soak
• 3OX0 – Free
• 3OXB – Single mutant
• 3OXD – Double mutant

2′-deoxyguanosine riboswitch

Nat. Chem. Biol. 2011

• 3SKI – Bound to 2′-deoxuguanosine
• 3SKL – Iridium hexammine soak
• 3SKR – Cobalt hexammine soak
• 3SKT – Mn²⁺ soak
• 3SKW – Cs²⁺ soak
• 3SKZ – Bound to guanosine
• 3SLM – Bound to 2′-deoxyguanosine-5′-monophosphate
• 3SLQ – Bound to guanosine-5′-monophosphate

Tetrahydrofolate riboswitch

Proc. Natl. Acad. Sci. USA 2011

• 3SUH – Bound to 5-formyl-THF
• 3SUX – Bound to THF
• 3SUY – Free

Vitamin B₁₂ riboswitch

Nat. Struct. Mol. Biol. 2012

• 4GXY

c-di-AMP riboswitch

Nat. Chem. Biol. 2014

• 4QK8 – Thermoanaerobacter pseudethanolicus riboswitch
• 4QK9 – Thermovirga lienii riboswitch
• 4QKA – Thermoanaerobacter pseudethanolicus riboswitch, iridium hexammine soak

RppH bound to RNA and in free state

J Biol. Chem. 2015

• 4S2V – Free RppH, KI soak
• 4S2W – Free RppH, sulfate bound
• 4S2X – RppH-RNA with two Mg²⁺ cations
• 4S2Y – RppH-RNA with three Mg²⁺ cations

Complex between human FMRP RGG motif and G-quadruplex RNA

Proc. Natl. Acad. Sci. U.S.A. 2015

• 5DE5
• 5DE8 – Iridium hexammine soak
• 5DE8 – Cs⁺ soak